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A Bipartite Autoinhibitory Region within the B-domain Suppresses Function in Factor V
Activation of blood coagulation factor V (FV) is a key reaction of hemostasis. FV circulates in plasma as an inactive procofactor, and proteolytic removal of a large central B-domain converts it to an active cofactor (FVa) for factor Xa (FXa). Here we show that two short evolutionary conserved segme...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3406718/ https://ncbi.nlm.nih.gov/pubmed/22707727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.377168 |
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