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Restoring the Procofactor State of Factor Va-like Variants by Complementation with B-domain Peptides
Coagulation factor V (FV) circulates as an inactive procofactor and is activated to FVa by proteolytic removal of a large inhibitory B-domain. Conserved basic and acidic sequences within the B-domain appear to play an important role in keeping FV as an inactive procofactor. Here, we utilized recombi...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Biochemistry and Molecular Biology
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3798483/ https://ncbi.nlm.nih.gov/pubmed/24014022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.506840 |
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