Interaction of factor V B-domain acidic region with its basic region and with TFPI/TFPI2: Structural insights from molecular modeling studies

BACKGROUND: Factor V (FV) B-domain contains an acidic region (FV-AR2) and a basic region (FV-BR), which interact with each other and maintain FV in a procofactor form; removal of either region via deletion/proteolysis results in an active FVa molecule. Tissue factor pathway inhibitor type-1 (TFPI) a...

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Detaylı Bibliyografya
Yayımlandı:Int Biol Rev
Asıl Yazarlar: Vadivel, Kanagasabai, Kumar, Yogesh, Bunce, Matthew W., Camire, Rodney M., Bajaj, Madhu S., Bajaj, S. Paul
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568831/
https://ncbi.nlm.nih.gov/pubmed/28845483
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