Platelets Contain Tissue Factor Pathway Inhibitor-2 Derived from Megakaryocytes and Inhibits Fibrinolysis

Tissue factor pathway inhibitor-2 (TFPI-2) is a homologue of TFPI-1 and contains three Kunitz-type domains and a basic C terminus region. The N-terminal domain of TFPI-2 is the only inhibitory domain, and it inhibits plasma kallikrein, factor XIa, and plasmin. However, plasma TFPI-2 levels are negli...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Vadivel, Kanagasabai, Ponnuraj, Sathya-Moorthy, Kumar, Yogesh, Zaiss, Anne K., Bunce, Matthew W., Camire, Rodney M., Wu, Ling, Evseenko, Denis, Herschman, Harvey R., Bajaj, Madhu S., Bajaj, S. Paul
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4223360/
https://ncbi.nlm.nih.gov/pubmed/25262870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.569665
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