CD8(+) T Cells from Mice Transnuclear for a TCR that Recognizes a Single H-2K(b)-Restricted MHV68 Epitope Derived from gB-ORF8 Help Control Infection

To study the CD8(+) T cell response against a mouse γ-herpes virus, we generated K(b)-MHV-68-ORF8(604–612) RAG(−/−) CD8(+) T cell receptor transnuclear (TN) mice as a source of virus-specific CD8(+) T cells. K(b)-ORF8-Tet(+) CD8(+) T cells, expanded in the course of a resolving MHV-68 infection, ser...

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Bibliografiske detaljer
Main Authors: Sehrawat, Sharvan, Kirak, Oktay, Koenig, Paul-Albert, Isaacson, Marisa K., Marques, Sofia, Bozkurt, Gunes, Simas, J. Pedro, Jaenisch, Rudolph, Ploegh, Hidde L.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3406328/
https://ncbi.nlm.nih.gov/pubmed/22832272
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2012.03.009
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