Dihydropyrimidine dehydrogenase polymorphisms and fluoropyrimidine toxicity: ready for routine clinical application within personalized medicine?

Fluoropyrimidines, including 5-fluorouracil (5-FU), are widely used in the treatment of solid tumors and remain the backbone of many combination regimens. Despite their clinical benefit, fluoropyrimidines are associated with gastrointestinal and hematologic toxicities, which often lead to treatment...

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מידע ביבליוגרפי
Main Authors: Del Re, Marzia, Di Paolo, Antonello, van Schaik, Ron H., Bocci, Guido, Simi, Paolo, Falcone, Alfredo, Danesi, Romano
פורמט: Artigo
שפה:Inglês
יצא לאור: Springer Netherlands 2010
נושאים:
Review Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405332/
https://ncbi.nlm.nih.gov/pubmed/23199091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13167-010-0041-2
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