Dihydropyrimidine dehydrogenase polymorphisms and fluoropyrimidine toxicity: ready for routine clinical application within personalized medicine?

Fluoropyrimidines, including 5-fluorouracil (5-FU), are widely used in the treatment of solid tumors and remain the backbone of many combination regimens. Despite their clinical benefit, fluoropyrimidines are associated with gastrointestinal and hematologic toxicities, which often lead to treatment...

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Autori principali: Del Re, Marzia, Di Paolo, Antonello, van Schaik, Ron H., Bocci, Guido, Simi, Paolo, Falcone, Alfredo, Danesi, Romano
Natura: Artigo
Lingua:Inglês
Pubblicazione: Springer Netherlands 2010
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Review Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405332/
https://ncbi.nlm.nih.gov/pubmed/23199091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13167-010-0041-2
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