Strong Association of a Common Dihydropyrimidine Dehydrogenase Gene Polymorphism with Fluoropyrimidine-Related Toxicity in Cancer Patients

BACKGROUND: Cancer patients carrying mutations in the dihydropyrimidine dehydrogenase gene (DPYD) have a high risk to experience severe drug-adverse effects following chemotherapy with fluoropyrimidine drugs such as 5-fluorouracil (5-FU) or capecitabine. The pretreatment detection of this impairment...

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Main Authors: Gross, Eva, Busse, Birgit, Riemenschneider, Matthias, Neubauer, Steffi, Seck, Katharina, Klein, Hanns-Georg, Kiechle, Marion, Lordick, Florian, Meindl, Alfons
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2602733/
https://ncbi.nlm.nih.gov/pubmed/19104657
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004003
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