Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing

The fluoropyrimidines are the mainstay chemotherapeutic agents for the treatment of many types of cancers. Detoxifying metabolism of fluoropyrimidines requires dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene), and reduced or absent activity of this enzyme can result in severe, and som...

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Main Authors: Caudle, K E, Thorn, C F, Klein, T E, Swen, J J, McLeod, H L, Diasio, R B, Schwab, M
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2013
主題:
CPIC Guidelines
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831181/
https://ncbi.nlm.nih.gov/pubmed/23988873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.172
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