Clinical Pharmacogenetics Implementation Consortium (CPIC) Guidelines for Ivacaftor Therapy in the Context of CFTR Genotype

Cystic fibrosis (CF) is a life-shortening disease arising as a consequence of mutations within the CFTR gene. Novel therapeutics for CF are emerging that target CF transmembrane conductance regulator protein (CFTR) defects resulting from specific CFTR variants. Ivacaftor is a drug that potentiates C...

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Autors principals: Clancy, J P, Johnson, S G, Yee, S W, McDonagh, E M, Caudle, K E, Klein, T E, Cannavo, M, Giacomini, K M
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2014
Matèries:
CPIC Guidelines
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4026598/
https://ncbi.nlm.nih.gov/pubmed/24598717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2014.54
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