Clinical Pharmacogenetics Implementation Consortium Guidelines for Dihydropyrimidine Dehydrogenase Genotype and Fluoropyrimidine Dosing

The fluoropyrimidines are the mainstay chemotherapeutic agents for the treatment of many types of cancers. Detoxifying metabolism of fluoropyrimidines requires dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene), and reduced or absent activity of this enzyme can result in severe, and som...

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Kaydedildi:
Detaylı Bibliyografya
Asıl Yazarlar: Caudle, K E, Thorn, C F, Klein, T E, Swen, J J, McLeod, H L, Diasio, R B, Schwab, M
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2013
Konular:
CPIC Guidelines
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831181/
https://ncbi.nlm.nih.gov/pubmed/23988873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2013.172
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