Discovery of novel mutations in the dihydropyrimidine dehydrogenase gene associated with toxicity of fluoropyrimidines and viewpoint on preemptive pharmacogenetic screening in patients

BACKGROUND: Dihydropyrimidine dehydrogenase (DPD) is the initial and rate-limiting enzyme of the metabolic pathway of 5-fluorouracil (5-FU) and other fluoropyrimidines to inactive compounds. For this reason, severe, life-threatening toxicities may occur in patients with deficient DPD activity when a...

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Bibliographic Details
Published in:EPMA J
Main Authors: Del Re, Marzia, Michelucci, Angela, Di Leo, Angelo, Cantore, Maurizio, Bordonaro, Roberto, Simi, Paolo, Danesi, Romano
Format: Artigo
Language:Inglês
Published: BioMed Central 2015
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4556010/
https://ncbi.nlm.nih.gov/pubmed/26330892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13167-015-0039-x
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