TIGAR induces p53-mediated cell-cycle arrest by regulation of RB–E2F1 complex

BACKGROUND: p53 induces cell-cycle arrest and apoptosis in cancer cells and negatively regulates glycolysis via TIGAR. Glycolysis is crucial for cancer progression although TIGAR provides protection from reactive oxygen species and apoptosis. The relation between TIGAR-mediated inhibition of glycoly...

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Hlavní autoři: Madan, E, Gogna, R, Kuppusamy, P, Bhatt, M, Pati, U, Mahdi, A A
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405207/
https://ncbi.nlm.nih.gov/pubmed/22782351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.260
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