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TIGAR induces p53-mediated cell-cycle arrest by regulation of RB–E2F1 complex
BACKGROUND: p53 induces cell-cycle arrest and apoptosis in cancer cells and negatively regulates glycolysis via TIGAR. Glycolysis is crucial for cancer progression although TIGAR provides protection from reactive oxygen species and apoptosis. The relation between TIGAR-mediated inhibition of glycoly...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3405207/ https://ncbi.nlm.nih.gov/pubmed/22782351 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2012.260 |
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