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SCO2 Induces p53-Mediated Apoptosis by Thr(845) Phosphorylation of ASK-1 and Dissociation of the ASK-1–Trx Complex
p53 prevents cancer via cell cycle arrest, apoptosis, and the maintenance of genome stability. p53 also regulates energy-generating metabolic pathways such as oxidative phosphorylation (OXPHOS) and glycolysis via transcriptional regulation of SCO2 and TIGAR. SCO2, a cytochrome c oxidase assembly fac...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Microbiology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3624269/ https://ncbi.nlm.nih.gov/pubmed/23319048 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.06798-11 |
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