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Gallium compound GaQ(3)-induced Ca(2+) signalling triggers p53-dependent and -independent apoptosis in cancer cells

BACKGROUND AND PURPOSE: A novel anti-neoplastic gallium complex GaQ(3) (KP46), earlier developed by us, is currently in phase I clinical trial. GaQ(3) induced S-phase arrest and apoptosis via caspase/PARP cleavage in a variety of cancers. However, the underlying mechanism of apoptosis is unknown. He...

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Detalhes bibliográficos
Main Authors: Gogna, Rajan, Madan, Esha, Keppler, Bernhard, Pati, Uttam
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3417493/
https://ncbi.nlm.nih.gov/pubmed/22074401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01780.x
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