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Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells

Prostasin is a membrane-anchored protease expressed in airway epithelium, where it stimulates salt and water uptake by cleaving the epithelial Na(+) channel (ENaC). Prostasin is activated by another transmembrane tryptic protease, matriptase. Because ENaC-mediated dehydration contributes to cystic f...

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Detalhes bibliográficos
Main Authors: Nimishakavi, Shilpa, Besprozvannaya, Marina, Raymond, Wilfred W., Craik, Charles S., Gruenert, Dieter C., Caughey, George H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404626/
https://ncbi.nlm.nih.gov/pubmed/22582115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00303.2011
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