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Activity and inhibition of prostasin and matriptase on apical and basolateral surfaces of human airway epithelial cells
Prostasin is a membrane-anchored protease expressed in airway epithelium, where it stimulates salt and water uptake by cleaving the epithelial Na(+) channel (ENaC). Prostasin is activated by another transmembrane tryptic protease, matriptase. Because ENaC-mediated dehydration contributes to cystic f...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Physiological Society
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3404626/ https://ncbi.nlm.nih.gov/pubmed/22582115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00303.2011 |
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