The p110α and p110β isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis

Class Ia phosphatidylinositol 3 kinase (PI3K) is required for oncogenic receptor-mediated transformation; however, the individual roles of the two commonly expressed class Ia PI3K isoforms in oncogenic receptor signaling have not been elucidated in vivo. Here, we show that genetic ablation of p110α...

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Hlavní autoři: Utermark, Tamara, Rao, Trisha, Cheng, Hailing, Wang, Qi, Lee, Sang Hyun, Wang, Zhigang C., Iglehart, J. Dirk, Roberts, Thomas M., Muller, William J., Zhao, Jean J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2012
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404385/
https://ncbi.nlm.nih.gov/pubmed/22802530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.191973.112
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