SNP Calling, Genotype Calling, and Sample Allele Frequency Estimation from New-Generation Sequencing Data

We present a statistical framework for estimation and application of sample allele frequency spectra from New-Generation Sequencing (NGS) data. In this method, we first estimate the allele frequency spectrum using maximum likelihood. In contrast to previous methods, the likelihood function is calcul...

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Detalles Bibliográficos
Main Authors: Nielsen, Rasmus, Korneliussen, Thorfinn, Albrechtsen, Anders, Li, Yingrui, Wang, Jun
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404070/
https://ncbi.nlm.nih.gov/pubmed/22911679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037558
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