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SNP Calling, Genotype Calling, and Sample Allele Frequency Estimation from New-Generation Sequencing Data
We present a statistical framework for estimation and application of sample allele frequency spectra from New-Generation Sequencing (NGS) data. In this method, we first estimate the allele frequency spectrum using maximum likelihood. In contrast to previous methods, the likelihood function is calcul...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Public Library of Science
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3404070/ https://ncbi.nlm.nih.gov/pubmed/22911679 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037558 |
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