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Estimating inbreeding coefficients from NGS data: Impact on genotype calling and allele frequency estimation

Most methods for next-generation sequencing (NGS) data analyses incorporate information regarding allele frequencies using the assumption of Hardy–Weinberg equilibrium (HWE) as a prior. However, many organisms including those that are domesticated, partially selfing, or with asexual life cycles show...

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Main Authors: Vieira, Filipe G., Fumagalli, Matteo, Albrechtsen, Anders, Nielsen, Rasmus
格式: Artigo
語言:Inglês
出版: Cold Spring Harbor Laboratory Press 2013
主題:
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3814885/
https://ncbi.nlm.nih.gov/pubmed/23950147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.157388.113
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