N-Terminally Glutamate-Substituted Analogue of Gramicidin A as Protonophore and Selective Mitochondrial Uncoupler

Limited uncoupling of oxidative phosphorylation could be beneficial for cells by preventing excessive generation of reactive oxygen species. Typical uncouplers are weak organic acids capable of permeating across membranes with a narrow gap between efficacy and toxicity. Aimed at designing a nontoxic...

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Detalhes bibliográficos
Main Authors: Sorochkina, Alexandra I., Plotnikov, Egor Y., Rokitskaya, Tatyana I., Kovalchuk, Sergei I., Kotova, Elena A., Sychev, Sergei V., Zorov, Dmitry B., Antonenko, Yuri N.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404012/
https://ncbi.nlm.nih.gov/pubmed/22911866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041919
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