N-Terminally Glutamate-Substituted Analogue of Gramicidin A as Protonophore and Selective Mitochondrial Uncoupler

Limited uncoupling of oxidative phosphorylation could be beneficial for cells by preventing excessive generation of reactive oxygen species. Typical uncouplers are weak organic acids capable of permeating across membranes with a narrow gap between efficacy and toxicity. Aimed at designing a nontoxic...

Descripció completa

Guardat en:
Dades bibliogràfiques
Autors principals: Sorochkina, Alexandra I., Plotnikov, Egor Y., Rokitskaya, Tatyana I., Kovalchuk, Sergei I., Kotova, Elena A., Sychev, Sergei V., Zorov, Dmitry B., Antonenko, Yuri N.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404012/
https://ncbi.nlm.nih.gov/pubmed/22911866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041919
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars