Penetrating Cations Enhance Uncoupling Activity of Anionic Protonophores in Mitochondria

Protonophorous uncouplers causing a partial decrease in mitochondrial membrane potential are promising candidates for therapeutic applications. Here we showed that hydrophobic penetrating cations specifically targeted to mitochondria in a membrane potential-driven fashion increased proton-translocat...

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Detalhes bibliográficos
Main Authors: Antonenko, Yuri N., Khailova, Ljudmila S., Knorre, Dmitry A., Markova, Olga V., Rokitskaya, Tatyana I., Ilyasova, Tatyana M., Severina, Inna I., Kotova, Elena A., Karavaeva, Yulia E., Prikhodko, Anastasia S., Severin, Fedor F., Skulachev, Vladimir P.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633956/
https://ncbi.nlm.nih.gov/pubmed/23626747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061902
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