Penetrating Cations Enhance Uncoupling Activity of Anionic Protonophores in Mitochondria

Protonophorous uncouplers causing a partial decrease in mitochondrial membrane potential are promising candidates for therapeutic applications. Here we showed that hydrophobic penetrating cations specifically targeted to mitochondria in a membrane potential-driven fashion increased proton-translocat...

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Bibliographic Details
Main Authors: Antonenko, Yuri N., Khailova, Ljudmila S., Knorre, Dmitry A., Markova, Olga V., Rokitskaya, Tatyana I., Ilyasova, Tatyana M., Severina, Inna I., Kotova, Elena A., Karavaeva, Yulia E., Prikhodko, Anastasia S., Severin, Fedor F., Skulachev, Vladimir P.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633956/
https://ncbi.nlm.nih.gov/pubmed/23626747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061902
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