Penetrating Cations Enhance Uncoupling Activity of Anionic Protonophores in Mitochondria

Protonophorous uncouplers causing a partial decrease in mitochondrial membrane potential are promising candidates for therapeutic applications. Here we showed that hydrophobic penetrating cations specifically targeted to mitochondria in a membrane potential-driven fashion increased proton-translocat...

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Bibliographische Detailangaben
Hauptverfasser: Antonenko, Yuri N., Khailova, Ljudmila S., Knorre, Dmitry A., Markova, Olga V., Rokitskaya, Tatyana I., Ilyasova, Tatyana M., Severina, Inna I., Kotova, Elena A., Karavaeva, Yulia E., Prikhodko, Anastasia S., Severin, Fedor F., Skulachev, Vladimir P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2013
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3633956/
https://ncbi.nlm.nih.gov/pubmed/23626747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061902
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