N-Terminally Glutamate-Substituted Analogue of Gramicidin A as Protonophore and Selective Mitochondrial Uncoupler

Limited uncoupling of oxidative phosphorylation could be beneficial for cells by preventing excessive generation of reactive oxygen species. Typical uncouplers are weak organic acids capable of permeating across membranes with a narrow gap between efficacy and toxicity. Aimed at designing a nontoxic...

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Main Authors: Sorochkina, Alexandra I., Plotnikov, Egor Y., Rokitskaya, Tatyana I., Kovalchuk, Sergei I., Kotova, Elena A., Sychev, Sergei V., Zorov, Dmitry B., Antonenko, Yuri N.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404012/
https://ncbi.nlm.nih.gov/pubmed/22911866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041919
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