N-Terminally Glutamate-Substituted Analogue of Gramicidin A as Protonophore and Selective Mitochondrial Uncoupler

Limited uncoupling of oxidative phosphorylation could be beneficial for cells by preventing excessive generation of reactive oxygen species. Typical uncouplers are weak organic acids capable of permeating across membranes with a narrow gap between efficacy and toxicity. Aimed at designing a nontoxic...

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Auteurs principaux: Sorochkina, Alexandra I., Plotnikov, Egor Y., Rokitskaya, Tatyana I., Kovalchuk, Sergei I., Kotova, Elena A., Sychev, Sergei V., Zorov, Dmitry B., Antonenko, Yuri N.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3404012/
https://ncbi.nlm.nih.gov/pubmed/22911866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041919
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