IL-21 is critical for graft-versus-host disease in a mouse model

Immunological effects of IL-21 on T-, B-, and NK-cells have been reported, but the role for IL-21 in graft-versus-host disease (GVHD) remains obscure. Here we demonstrate that morbidity and mortality of GVHD was significantly reduced after bone marrow transplantation with splenocytes from IL-21R(−/−...

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Hauptverfasser: Meguro, A, Ozaki, K, Oh, I, Hatanaka, K, Matsu, H, Tatara, R, Sato, K, Leonard, WJ, Ozawa, K
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403836/
https://ncbi.nlm.nih.gov/pubmed/19718060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bmt.2009.223
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