Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells

Previously, we have shown that IL-21R(-/-) splenocytes ameliorate graft-versus-host disease (GVHD) as compared to wild type splenocytes. Here, we investigated whether or not IL-21R(-/-) splenocytes diminish the graft-versus-leukemia (GVL) effect. Surprisingly, IL-21R(-/-) splenocytes efficiently eli...

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Autors principals: Meguro, A, Ozaki, K, Hatanaka, K, Oh, I, Sudo, K, Ohmori, T, Matsu, H, Tatara, R, Sato, K, Sakata, Y, Nakae, S, Leonard, WJ, Ozawa, Keiya
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401481/
https://ncbi.nlm.nih.gov/pubmed/21258423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bmt.2010.342
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