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Lack of IL-21 signal attenuates graft-versus-leukemia effect in the absence of CD8 T-cells
Previously, we have shown that IL-21R(-/-) splenocytes ameliorate graft-versus-host disease (GVHD) as compared to wild type splenocytes. Here, we investigated whether or not IL-21R(-/-) splenocytes diminish the graft-versus-leukemia (GVL) effect. Surprisingly, IL-21R(-/-) splenocytes efficiently eli...
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| Autori principali: | , , , , , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3401481/ https://ncbi.nlm.nih.gov/pubmed/21258423 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bmt.2010.342 |
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