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IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation
Interleukin-21 (IL-21) enhances T helper 1 (Th1) and Th17 differentiation while inhibiting the conversion of inducible regulatory T cells (Tregs) from naive T cells. To determine the role of IL-21 in graft-versus-host disease (GVHD), anti–IL-21 antibody (Ab) was given to recipients of CD25(−)CD4(+)...
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| Hlavní autoři: | , , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Society of Hematology
2009
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2796140/ https://ncbi.nlm.nih.gov/pubmed/19843883 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-221135 |
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