IL-21 blockade reduces graft-versus-host disease mortality by supporting inducible T regulatory cell generation

Interleukin-21 (IL-21) enhances T helper 1 (Th1) and Th17 differentiation while inhibiting the conversion of inducible regulatory T cells (Tregs) from naive T cells. To determine the role of IL-21 in graft-versus-host disease (GVHD), anti–IL-21 antibody (Ab) was given to recipients of CD25(−)CD4(+)...

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Bibliographic Details
Main Authors: Bucher, Christoph, Koch, Lisa, Vogtenhuber, Christine, Goren, Emily, Munger, Meghan, Panoskaltsis-Mortari, Angela, Sivakumar, Pallavur, Blazar, Bruce R.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2009
Subjects:
Transplantation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2796140/
https://ncbi.nlm.nih.gov/pubmed/19843883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-05-221135
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