Constitutively active Stat5b in CD4(+) T cells inhibits graft-versus-host disease lethality associated with increased regulatory T-cell potency and decreased T effector cell responses

Overexpression of a constitutively active form of Stat5b (Stat5b-CA) increases regulatory T cells (Tregs). We show that Stat5b-CA transgenic (TG) CD4(+) T cells had a markedly reduced graft-versus-host disease (GVHD) capacity versus wild-type (WT) T cells. Stat5b-CA TG versus WT CD4(+) T cells had a...

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Bibliografiska uppgifter
Huvudupphovsmän: Vogtenhuber, Christine, Bucher, Christoph, Highfill, Steven L., Koch, Lisa K., Goren, Emily, Panoskaltsis-Mortari, Angela, Taylor, Patricia A., Farrar, Michael A., Blazar, Bruce R.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2010
Ämnen:
Transplantation
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2913456/
https://ncbi.nlm.nih.gov/pubmed/20442366
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-11-252825
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