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Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells
CC-chemokine receptor 7 (CCR7) is expressed on the surface of naive T cells, and plays a critical role in their movement into secondary lymphoid tissue. Here, we show that murine T cells lacking CCR7 (CCR7(−/−)) generate attenuated graft-versus-host disease (GVHD) responses compared with wild-type (...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2890182/ https://ncbi.nlm.nih.gov/pubmed/20185583 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-239848 |
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