Separation of graft-versus-host disease from graft-versus-leukemia responses by targeting CC-chemokine receptor 7 on donor T cells

CC-chemokine receptor 7 (CCR7) is expressed on the surface of naive T cells, and plays a critical role in their movement into secondary lymphoid tissue. Here, we show that murine T cells lacking CCR7 (CCR7(−/−)) generate attenuated graft-versus-host disease (GVHD) responses compared with wild-type (...

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Библиографические подробности
Главные авторы: Coghill, James M., Carlson, Michael J., Panoskaltsis-Mortari, Angela, West, Michelle L., Burgents, Joseph E., Blazar, Bruce R., Serody, Jonathan S.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2010
Предметы:
Transplantation
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2890182/
https://ncbi.nlm.nih.gov/pubmed/20185583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-08-239848
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