Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality

Graft-versus-host disease (GVHD) is initiated after activation of donor T cells by host antigen-presenting cells (APCs). The immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by APCs and parenchymal cells and is further inducible by inflammation. We investigated whether lethal...

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Detalhes bibliográficos
Main Authors: Jasperson, Lisa K., Bucher, Christoph, Panoskaltsis-Mortari, Angela, Taylor, Patricia A., Mellor, Andrew L., Munn, David H., Blazar, Bruce R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2008
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2265461/
https://ncbi.nlm.nih.gov/pubmed/18077788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-096081
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