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Indoleamine 2,3-dioxygenase is a critical regulator of acute graft-versus-host disease lethality
Graft-versus-host disease (GVHD) is initiated after activation of donor T cells by host antigen-presenting cells (APCs). The immunosuppressive enzyme indoleamine 2,3-dioxygenase (IDO) is expressed by APCs and parenchymal cells and is further inducible by inflammation. We investigated whether lethal...
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| Autors principals: | , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2265461/ https://ncbi.nlm.nih.gov/pubmed/18077788 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-06-096081 |
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