Contrasting acute graft-versus-host disease effects of Tim-3/galectin-9 pathway blockade dependent upon the presence of donor regulatory T cells

T-cell immunoglobulin mucin-3 (Tim-3) is expressed on pathogenic T cells, and its ligand galectin-9 (gal-9) is up-regulated in inflamed tissues. When Tim-3(+) T cells encounter high gal-9 levels, they are deleted. Tim-3 is up-regulated on activated T cells during GVHD. Inhibition of Tim-3/gal-9 bind...

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Detalhes bibliográficos
Main Authors: Veenstra, Rachelle G., Taylor, Patricia A., Zhou, Qing, Panoskaltsis-Mortari, Angela, Hirashima, Mitsuomi, Flynn, Ryan, Liu, Derek, Anderson, Ana C., Strom, Terry B., Kuchroo, Vijay K., Blazar, Bruce R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2012
Assuntos:
Transplantation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401220/
https://ncbi.nlm.nih.gov/pubmed/22677125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-387977
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