Coexpression of Tim-3 and PD-1 identifies a CD8(+) T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia

Tumor-associated immune suppression can lead to defective T cell-mediated antitumor immunity. Here, we identified a unique phenotype of exhausted T cells in mice with advanced acute myelogenous leukemia (AML). This phenotype is characterized by the coexpression of Tim-3 and PD-1 on CD8(+) T cells in...

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Hlavní autoři: Zhou, Qing, Munger, Meghan E., Veenstra, Rachelle G., Weigel, Brenda J., Hirashima, Mitsuomi, Munn, David H., Murphy, William J., Azuma, Miyuki, Anderson, Ana C., Kuchroo, Vijay K., Blazar, Bruce R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2011
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3099570/
https://ncbi.nlm.nih.gov/pubmed/21385853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-310425
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