Substrate-Ligand Interactions in Geobacillus Stearothermophilus Nitric Oxide Synthase()

Ntric oxide synthase (NOS) generates NO via a sequential two-step reaction, L-arginine (L-Arg) → N-hydroxy-L-arginine (NOHA) → L-citrulline + NO. Each step of the reaction follows a distinct mechanism defined by the chemical environment introduced by each substrate bound to the heme active site. The...

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Bibliographic Details
Main Authors: Kabir, Mariam, Sudhamsu, Jawahar, Crane, Brian R., Yeh, Syun-Ru, Rousseau, Denis L.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3403685/
https://ncbi.nlm.nih.gov/pubmed/18956884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801491e
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