Catalytic Intermediates of Inducible Nitric-oxide Synthase Stabilized by the W188H Mutation()

Nitric-oxide synthase (NOS) catalyzes nitric oxide (NO) synthesis via a two-step process: l-arginine (l-Arg) →N-hydroxy-l-arginine →citrulline + NO. In the active site the heme is coordinated by a thiolate ligand, which accepts a H-bond from a nearby tryptophan residue, Trp-188. Mutation of Trp-188...

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Bibliografiska uppgifter
Huvudupphovsmän: Sabat, Joseph, Egawa, Tsuyoshi, Lu, Changyuan, Stuehr, Dennis J., Gerfen, Gary J., Rousseau, Denis L., Yeh, Syun-Ru
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2013
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3816742/
https://ncbi.nlm.nih.gov/pubmed/23269673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.403238
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