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Catalytic Intermediates of Inducible Nitric-oxide Synthase Stabilized by the W188H Mutation()
Nitric-oxide synthase (NOS) catalyzes nitric oxide (NO) synthesis via a two-step process: l-arginine (l-Arg) →N-hydroxy-l-arginine →citrulline + NO. In the active site the heme is coordinated by a thiolate ligand, which accepts a H-bond from a nearby tryptophan residue, Trp-188. Mutation of Trp-188...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3816742/ https://ncbi.nlm.nih.gov/pubmed/23269673 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.403238 |
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