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Rapamycin down-regulates KCC2 expression and increases seizure susceptibility to convulsants in immature rats

Seizure susceptibility to neurological insults, including chemical convulsants, is age-dependent and most likely reflective of overall differences in brain excitability. The molecular and cellular mechanisms underlying development-dependent seizure susceptibility remain to be fully understood. Becau...

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Autors principals: Huang, Xiaoxing, McMahon, John, Yang, Jun, Shin, Damian, Huang, Yunfei
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402618/
https://ncbi.nlm.nih.gov/pubmed/22613737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2012.05.003
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