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Seizure-dependent mTOR activation in 5-HT neurons promotes autism-like behaviors in mice

Epilepsy and autism spectrum disorder (ASD) are common comorbidities of one another. Despite the prevalent correlation between the two disorders, few studies have been able to elucidate a mechanistic link. We demonstrate that forebrain specific Tsc1 deletion in mice causes epilepsy and autism-like b...

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Detalhes bibliográficos
Publicado no:Neurobiol Dis
Main Authors: McMahon, John J., Yu, Wilson, Yang, Jun, Feng, Haihua, Helm, Meghan, McMahon, Elizabeth, Zhu, Xinjun, Shin, Damian, Huang, Yunfei
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394017/
https://ncbi.nlm.nih.gov/pubmed/25315683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.10.004
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