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Seizure-dependent mTOR activation in 5-HT neurons promotes autism-like behaviors in mice

Epilepsy and autism spectrum disorder (ASD) are common comorbidities of one another. Despite the prevalent correlation between the two disorders, few studies have been able to elucidate a mechanistic link. We demonstrate that forebrain specific Tsc1 deletion in mice causes epilepsy and autism-like b...

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Podrobná bibliografie
Vydáno v:Neurobiol Dis
Hlavní autoři: McMahon, John J., Yu, Wilson, Yang, Jun, Feng, Haihua, Helm, Meghan, McMahon, Elizabeth, Zhu, Xinjun, Shin, Damian, Huang, Yunfei
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394017/
https://ncbi.nlm.nih.gov/pubmed/25315683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.10.004
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