Seizure-dependent mTOR activation in 5-HT neurons promotes autism-like behaviors in mice

Epilepsy and autism spectrum disorder (ASD) are common comorbidities of one another. Despite the prevalent correlation between the two disorders, few studies have been able to elucidate a mechanistic link. We demonstrate that forebrain specific Tsc1 deletion in mice causes epilepsy and autism-like b...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurobiol Dis
Prif Awduron: McMahon, John J., Yu, Wilson, Yang, Jun, Feng, Haihua, Helm, Meghan, McMahon, Elizabeth, Zhu, Xinjun, Shin, Damian, Huang, Yunfei
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2014
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4394017/
https://ncbi.nlm.nih.gov/pubmed/25315683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2014.10.004
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