A Novel Class of Anti-HIV Agents with Multiple Copies of Enfuvirtide Enhances Inhibition of Viral Replication and Cellular Transmission In Vitro

We constructed novel HIV-1 fusion inhibitors that may overcome the current limitations of enfuvirtide, the first such therapeutic in this class. The three prototypes generated by the Dock-and-Lock (DNL) technology to comprise four copies of enfuvirtide tethered site-specifically to the Fc end of dif...

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Bibliografiska uppgifter
Huvudupphovsmän: Chang, Chien-Hsing, Hinkula, Jorma, Loo, Meiyu, Falkeborn, Tina, Li, Rongxiu, Cardillo, Thomas M., Rossi, Edmund A., Goldenberg, David M., Wahren, Britta
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2012
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3402531/
https://ncbi.nlm.nih.gov/pubmed/22844444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0041235
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