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A new class of bispecific antibodies to redirect T cells for cancer immunotherapy

Various constructs of bispecific antibodies (bsAbs) to redirect effector T cells for the targeted killing of tumor cells have shown considerable promise in both preclinical and clinical studies. The single-chain variable fragment (scFv)-based formats, including bispecific T-cell engager (BiTE) and d...

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Detalhes bibliográficos
Main Authors: Rossi, Diane L, Rossi, Edmund A, Cardillo, Thomas M, Goldenberg, David M, Chang, Chien-Hsing
Formato: Artigo
Idioma:Inglês
Publicado em: Landes Bioscience 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3984327/
https://ncbi.nlm.nih.gov/pubmed/24492297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/mabs.27385
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