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Novel Inhibitors for PRMT1 Discovered by High–Throughput Screening Using Activity–Based Fluorescence Polarization

Protein Arginine Methyltransferases (PRMTs) catalyze the posttranslational methylation of arginine using S–adenosyl–methionine (SAM) as a methyl–donor. The PRMT family is widely expressed and has been implicated in biological functions such as RNA splicing, transcriptional control, signal transducti...

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Autori principali: Dillon, Myles B. C., Bachovchin, Daniel A., Brown, Steven J., Finn, M.G., Rosen, Hugh, Cravatt, Benjamin F., Mowen, Kerri A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3401332/
https://ncbi.nlm.nih.gov/pubmed/22506763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300024c
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