Fhit tumor suppressor: guardian of the preneoplastic genome

Environmental agents induce intragenic alterations in the FRA3B/FHIT chromosome fragile site, resulting in fragile FHIT allele loss early in cancer development. Fhit knockout mice are predisposed to tumor development and Fhit gene therapy reduces tumor burden. Repair-deficient cancers are likely to...

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Bibliographic Details
Main Authors: Pichiorri, Flavia, Palumbo, Tiziana, Suh, Sung-Suk, Okamura, Hiroshi, Trapasso, Francesco, Ishii, Hideshi, Huebner, Kay, Croce, Carlo M
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400506/
https://ncbi.nlm.nih.gov/pubmed/19086848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/14796694.4.6.815
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