Fhit–Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells

Fhit protein is lost in cancers of most, perhaps all, cancer types; when restored, it can induce apoptosis and suppress tumorigenicity, as shown in vitro and in mouse tumor models in vivo. Following protein cross-linking and proteomics analyses, we characterized a Fhit protein complex involved in tr...

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Udgivet i:Cell Death Dis
Main Authors: Druck, Teresa, Cheung, Douglas G., Park, Dongju, Trapasso, Francesco, Pichiorri, Flavia, Gaspari, Marco, Palumbo, Tiziana, Aqeilan, Rami I., Gaudio, Eugenio, Okumura, Hiroshi, Iuliano, Rodolfo, Raso, Cinzia, Green, Kari, Huebner, Kay, Croce, Carlo M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6377664/
https://ncbi.nlm.nih.gov/pubmed/30770797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1414-7
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