Fhit Interaction with Ferredoxin Reductase Triggers Generation of Reactive Oxygen Species and Apoptosis of Cancer Cells

Fhit protein is lost in most cancers, its restoration suppresses tumorigenicity, and virus-mediated FHIT gene therapy induces apoptosis and suppresses tumors in preclinical models. We have used protein cross-linking and proteomics methods to characterize a Fhit protein complex involved in triggering...

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Detalhes bibliográficos
Main Authors: Trapasso, Francesco, Pichiorri, Flavia, Gaspari, Marco, Palumbo, Tiziana, Aqeilan, Rami I., Gaudio, Eugenio, Okumura, Hiroshi, Iuliano, Rodolfo, Di Leva, Giampiero, Fabbri, Muller, Birk, David E., Raso, Cinzia, Green-Church, Kari, Spagnoli, Luigi G., Venuta, Salvatore, Huebner, Kay, Croce, Carlo M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2008
Assuntos:
Mechanisms of Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376222/
https://ncbi.nlm.nih.gov/pubmed/18319262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709062200
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