Endocannabinoid Enzyme Engineering: Soluble Human Thio-Monoacylglycerol Lipase (sol-S-hMGL)

[Image: see text] In the mammalian central nervous system, monoacylglycerol lipase (MGL) is principally responsible for inactivating the endocannabinoid signaling lipid 2-arachidonoylglycerol (2-AG) and modulates cannabinoid-1 receptor (CB1R) desensitization and signal intensity. MGL is also a drug...

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Main Authors: Karageorgos, Ioannis, Zvonok, Nikolai, Janero, David R., Vemuri, V. Kiran, Shukla, Vidyanand, Wales, Thomas E., Engen, John R., Makriyannis, Alexandros
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2012
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3400385/
https://ncbi.nlm.nih.gov/pubmed/22860208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn3000263
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